Natural Product Chemist
Natural products to chemists - molecules of communication to living organisms such as bacteria, fungi, and plants - secondary metabolites are chemicals that are involved in niche adaptations and ecological relationships. Perhaps due to this fitness role, natural products are marked by chemical diversity, an abundance of oxygen & nitrogen functionalities, and exquisite complexity of structure. Because they are produced for inter and intra species interactions, they are likely under selective pressure to produce at least some bioactive structures. Natural product chemical diversity, complexity and bioactivity drives the continual interests in these specialized organic metabolites .
Group members are undergraduate and graduate students. Researchers come from chemistry, biochemistry, biology and biotechnology backgrounds.
We are interested in working with the biological diversity of the northern forests of North Western Canada -Yukon Territories, British Columbia, and Alberta- to uncover the chemical potential of unknown bacterial natural products. From this biodiverse niche, we seek to retrieve unique chemical structures, natural product families of polyketide-nonribosomal peptides hybrids, and natural products with antifungal activity.
In order to do so, we make use of traditional organic chemistry techniques such as extraction ,chromatography, spectroscopy and synthesis to understand the structures and reactivity of these secondary metabolite natural products. We make use of various synthetic technologies to explore more sustainable production of natural product chemistry with use as nutraceuticals and pharmaceuticals. We also harness secondary metabolite bioinformatic tools to explore genetically encoded bacterial natural product chemistry and their gene cluster families.
Microbiology and molecular biology tools are utilized to isolate the bacteria from northern forest niches, particularly insects, and to identify the bacterial isolates. Bioinformatic tools are utilized to understand the genetic-encoding for the production of the complex natural product structures. We are particularly interested in the bacterial genera: Streptomyces, Burkeholderia and Bacillus; yet have a broad interest in all forest microbiome participants including fungi